| Shop and Ship Online | Rivonia, Johannesburg | Full Apple product range, PC & Electronics online | |
| Shop Hoa Tuoi B?o Hân | | Shop Hoa tuoi B?o Hân | |
| Shop n Sell | ladysmith | Classifieds | |
| Shoparcade.com | | gifts delivery | |
| Shopdisplay SA cc- Shopfitting and Display St | Durban | Shopfitting, joinery, cabinetry, display stands | |
| Shopfitting Concepts | Pretoria | Manufacturing | |
| ShopFront | Gauteng | SHOP DISPLAYS & EQUIPMENT, WE SELL SLAT BOARDS, | |
| ShopLI | Durban | Design/development of online stores/catalogues | |
| ShopNDeliver | Johannesburg | Grocery shopping and delivery | |
| ShoppingFeeder | Cape Town | Feed Management for Digital Agencies | |
| Shopstar | Cape Town | Launch your own online shop in under 5 mins. | |
| Short Term Loans | Mr Cash Loans | Alberton | Loans | |
| Short&Sweet | Cape Town | Short film curation, exhibition, distribution | |
| Shortwave Productions | Johannesburg | Audio Post Production, Location Sound Recording | |
| SHOSPEC | Pietermaritzburg | Shopfitting | |
| Shot by Jeanne | Pretoria | conceptual photography and corporate photography | |
| Show TV | Johannesburg | Video, Photographic & Graphic Design Company | |
| ShowMe Pretoria | Pretoria | Website Development/Online Marketing | |
| ShowSpen | Tzaneen | Streaming services | |
| Shriram City Union Finance | | Finance | |
| Shriram Transport Finance Company.Redhills | Chennai, Tamil Nadu | Finance & Insurance | |
| Shriram Transport Finance Company.Shrawasti | Shrawasti, Uttar Pradesh | finance & insurance | |
| Shubone Events | johannsburg | wedding and event planning,Hiring services,florist | |
| Shumba Connect | | telecommunications | |
| Shumu Protection Services | Cape Town | Security Guarding | |
| Shutterbabe Snapshots | Issaquah | Photography | |
| Shuttle King | Johannesburg | Johannesburg Airport Transfers, Shuttle Service | |
| Sianaa | | displayed when | |
| Sibanzima Inspections | Midrand | Inspection of pressure vessels and compressors | |
| Sibayeni Events & Conference Centre | Komatipoort | Events & Conference Facility | |
| Sichri - Eyewear Straps | Port Elizabeth | accessories | |
| Sichri Eyewear Straps | Port Elizabeth | Manufacturing eyewear straps | |
| Sicon Group | Boksburg | Roof Contractor | |
| Side Hustle Boss | Port Edward | Digital Online Marketing | |
| Side Kick Branding | Orange Grove | Marketing | |
| Sidebar International Inc | Cape Town | Marketing Agency | |
| Sidekick Branding | Johannesburg | Signage Branding | |
| Sidewinder Dry Ice & Gas | Cape Town | Manufacture and supplier of dry ice products | |
| Sight & Sound | Cape Town | Audio visual Hire and Staging | |
| Sigmatilers | Cape Town | Tilers builders | |
| Sign Franchise | Sandton | Franchising | |
| Sign Image | Pretoria | Signage Company Gauteng | |
| Sign Image Digital | Pretoria | Signage, safety signs, poster frames, | |
| Sign Odyssey | Durban | Signage and Digital Print | |
| Sign Wonder | Alberton | Signage, Digital Printing | |
| Sign Wonder cc | Gauteng | Vehicle Branding, Promotional Printing | |
| Sign360 PMB | Pietermaritzburg | Signage and Branding | |
| Signa Academy | Randburg | Skills Development & Learning Programmes | |
| Signa Artisans | Boksburg | Artisans Training | |
| Signa Group | Randburg | B-BBEE Consulting, Services, Solutions | |
| Signa Higher Education | Randburg | Bursary Management | |
| Signa Opportunity | Randburg | Youth Employment Services (YES) | |
| Signa Trust | Randburg | Female Student Support | |
| Signarama | Sandton | Signage | |
| Signature Brand Clothing | Bloemfontein | Manufacture local designs | |
| Signature Design | Cape Town | Graphic Design | |
| Signature Productions | Cape Town | Events Management | |
| Signature Windows and Doors | Stockton-On-Tees | Home Impovements, Window Installers | |
| SignForce | Johannesburg | Signage manufacture and installation in Africa | |
| SignForce South Africa | Johannesburg | Design manufacture & install signage CI | |
| Signium Africa | Johannesburg | C-suite and executive level talent sourcing | |
| Signs Of Arts | Cape town | wall murals signwriting art projects | |
| Signs360 | Johannesburg | Signage and Branding | |
| Signs4SA | Pretoria | Signage | |
| Signs4SA.co.za | Pretoria | Signage, Print, Branding and Retail Solutions | |
| Sigudlasitsuppliers | Johannesburg | Webdesign photo video motivation speaker branding | |
| Sikhosim Investment | BOKSBURG | Residential Rentals, Transportation, Car shuttling | |
| Sikwantu Npc | Cape Town | Marketing | |
| Silent Rock Productions | Johannesburg | Television and corporate video production | |
| Silkmusic Wedding Djs | Cape Town | Wedding DJ | |
| Silva 5 Pets | Germiston | Sell products for pets | |
| Silver Bullet Productions | Cape Town | Film & Content Production | |
| Silver Chalk Design Studio | Pretoria | Visual Communication Specialists | |
| Silver Cloud Accounting | Cape Town | Accounting, Payroll & Business Advisory Services | |
| Silver Lining | Cape Town | Source & supply Corporate Gifts & Clothing | |
| Silver Linings Technologies | Pietermaritzburg | Website Design and SEO | |
| Silver Moon Media | Virgina | Videography | |
| Silver Ribbon Events | Johannesburg | Party /Function Hire Equipment | |
| Silver Screen Productions CC | South Africa | Video Production | |
| Silver Sieves Capital | | Wall murals | |
| Silver Solutions T/A About Turn Logistics | Cape Towwn | International and Domestic Courier, Air Freight | |
| Silverline Print | Vanderbijlpark | Label design & print | |
| Silverworx Staffing Solutions | Umhlanga | catering, events, mobile bartenders, waiters | |
| SILVERZONE IMAGES PHOTOGRAPHY | Ballito | Photography | |
| Silwer Lining Photography | Roodepoort | Newborn, maternity, cake smash photography | |
| SIMcontrol | Cape Town | Business SIM Management Platform | |
| Similia Investments | Johannesburg | Health | |
| Simmon Garage Door | Wilmington | Garage | |
| Simon Barnett Web Design and Development | Cape Town | Front End Web Development, Web Design | |
| Simon Dippenaar & Associates | Cape Town | Law firm | |
